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Dear Customers,
Due to the company request, we are currently not selling Cyto Matrix products on our website. However, all the products are still available at all of our store locations.
For product inquiries & to place an order, kindly email us your request at info@villagevitaminstore.ca or call Port Credit Village Pharmacy at 905-278-7237.
Thanks
Village Vitamin Store
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An evidence-based blend of Calcium-D-Glucarate, DIM, I-3-C, and Sulforaphane to support proper estrogen metabolism through liver and digestive detoxification.
Indicated for the proper metabolism of estrogen, symptomatic control in estrogen-dominant health conditions and healthy cellular differentiation of breast and cervical tissues, through improved xenobiotic detoxification and supported liver function.
The human body is designed with intricate detoxification systems to eliminate unnecessary compounds such as food waste byproducts, physically inert metals and everyday chemicals. However, our detoxification systems are also needed to regulate steroid hormones such as estrogen. Suboptimal liver and digestive tract function, in combination with excessive exposure to xenoestrogens, can lead to enterohepatic recirculation of estrogens and ultimately create an estrogen- dominant state with negative health implications for the body. Thankfully, a number of natural compounds have been identified to promote proper estrogen detoxification and healthy hormone metabolism.
Indole-3-carbinol (I-3-C) is naturally found in cruciferous vegetables such as broccoli and cauliflower and it is well-known for its ability to support healthy estrogen metabolism. I-3-C upregulates the production of 2-OHE1, the protective form of estrogen that acts as an estrogen antagonist. 16-OHE1, on the other hand, has potent estrogenic and proliferative effects that oppose the action of 2-OHE1. Research has repeatedly shown that a higher ratio of 2-OHE1 to 16-OHE1 is protective against disease and desirable for improving symptoms in estrogen dominant conditions. I-3-C improves this ratio of estrogen metabolites.
Numerous trials have shown that this positive shift in estrogen metabolites, as a result of I-3-C supplementation, is advantageous for health outcomes. For example, I-3-C has been shown to improve estrogen ratios and health outcomes in women with cervical disease. Animal studies have also found that I-3-C can prevent unhealthy cellular differentiation in breast tissue. Not only does I-3-C promote a positive estrogen metabolite ratio, but it additionally influences the expression of multiple genes, such as tumor-suppressing gene p53 and BRCA1, that collectively support the healthy differentiation of hormonally sensitive tissues.
I-3-C is naturally metabolized in the body to provide multiple active compounds, including the predominant metabolite diindolylmethane (DIM). Although debate exists regarding whether DIM or I-3-C is most beneficial as a health supplement, each compound has its advantages. I-3-C provides the body with many active metabolites, while DIM appears to be a primary metabolite with a potent detoxification activity. Both compounds are well-researched and effective treatments for the proper regulation of estrogens in the body.
D-glucarate, or glucaric acid, is another natural compound found naturally in oranges, carrots, apples and broccoli, and it promotes the detoxification of excess hormones, various toxins and carcinogens by deactivating B-glucoronidase. B-glucoronidase is an enzyme produced by colonic microflora that can ‘reactivate’ compounds that had previously been neutralized by the liver, preventing the recirculation of these toxins in the body. Animal studies have found that large doses of calcium-D-glucarate can reduce estrogen levels in the blood by up to 23% and also favorably impact lipid balance. Quite simply, calcium-D-glucarate is one of the best known natural B-glucoronidase inhibitors and the best studied form to safely deliver D-glucarate.
Finally, sulphoraphane glucosinolate (SGS) is a naturally occurring compound that, like I-3-C and DIM, is also found in broccoli and cruciferous vegetables. Numerous clinical trials support its use in promoting healthy cellular differentiation through the removal of xenobiotics and powerful induction of phase 2 detoxification enzymes in the liver. For example, SGS has been shown to reduce the carcinogenic effects of aflatoxin exposure on liver tissue. SGS also has anti-inflammatory actions through the inhibition of nuclear factor kappaB (NFkB), prostaglandin E2 and tumor necrosis factor-alpha (TNF-a), it can reduce estrogen receptor expression in breast tissue and it has antimicrobial activity against pathogens such as H. pylori, S. pyogenes and S. aureus.
At three capsules per day, Cyto-Matrix’s Estro Matrix contains 200mg of I-3-C, 100mg of DIM, 1500mg of Calcium-D-Glucarate and 100mg of sulforaphane. Collectively, Estro Matrix provides evidence-based dosages of synergistic ingredients to offer targeted and ongoing hormonal support through the proper metabolism of estrogens.
| Ingredient | Amount |
|---|---|
| DIM | 33.3mg |
| Indole-3-Carbinol | 66.7mg |
| BroccoPhane (sprouts, Brassica oleracea var. italica) | 33.3mg |
| Calcium D-Glucarate (calcium saccharate) | 500mg |
Unit of Measure above
Each capsule.
Non-Medicinal Ingredients
Vegetable-grade magnesium stearate, microcrystalline cellulose. Capsule: hypromellose.
Directions
Adults: Take 2 capsules, once per day or as directed by a healthcare professional.
Indications
Helps to promote healthy estrogen balance and reduce the severity and duration of symptoms associated with recurrent breast pain. Provides antioxidants that help protect against cell damage caused by free radicals.
Warnings
Do not use if safety seal is broken. Consult a healthcare professional prior to use, especially if you are taking other medications or natural health products and to exclude the diagnosis of a serious cause of hormonal imbalance. Consult a healthcare professional if you are attempting to conceive, havea liver disorder or symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations) or if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice) or symptoms of low estrogen. If recurrent breast pain persists or worsen, consult a healthcare professional.
Contraindications
Do not use if you are pregnant or breastfeeding.
Village Vitamin Store does not provide professional medical advice. Our website is intended for informational purposes and product inquiries. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice. If you think you may have a medical emergency, immediately call your doctor or dial 911.
At Village Vitamin Store, we Always work hard to ensure the accuracy of the product images and information contained on our website. However, some manufacturing changes packaging or ingredients without notice. and, may be pending updates on our website. We always recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by Village Vitamin Store.
Probiotics:
Probiotics are refrigerated in our warehouse to ensure quality and optimal potency.
They are also shipped with a FREE ice pack. Although the product may not be cold when it arrives, the ice pack helps maintain a cooler temperature during transit.
Our team of experienced pharmacists, certified nutritionists, and skilled homeopathic doctors are here to guide you on your wellness journey! Whether you're curious about the right supplements for your needs, seeking holistic remedies, or simply want expert advice, we're here to help!
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