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Magnesium Bisglycinate vs Glycinate: Which is Better for You?

Magnesium Bisglycinate vs Glycinate: Which is Better for You?

Magnesium is one of the most important minerals for health, yet many people struggle to get enough from diet alone. If you’ve looked into magnesium supplements, you’ve probably seen two common forms: magnesium bisglycinate and magnesium glycinate. They sound almost identical, but are they the same? Which one should you take?

Quick Answer:
Magnesium bisglycinate and magnesium glycinate are both highly absorbable forms of magnesium. Bisglycinate is usually gentler on digestion and better tolerated for people with sensitive stomachs, while glycinate is widely used to support relaxation and sleep. The right choice depends on your individual health goals.


What Is Magnesium Glycinate?

Magnesium glycinate is formed when magnesium is bound to the amino acid glycine. Glycine itself has calming properties, which may enhance magnesium’s ability to support relaxation.

Key points about magnesium glycinate:

  • Known for its calming effect on the nervous system.

  • Often chosen for sleep support and stress management.

  • Well absorbed, but in some cases may cause mild digestive discomfort.


What Is Magnesium Bisglycinate?

Magnesium bisglycinate is magnesium bound to two glycine molecules (“bis” = two). This small difference in structure makes it a popular option for people who want a supplement that’s both effective and gentle on the stomach.

Key points about magnesium bisglycinate:

  • Considered one of the most bioavailable forms of magnesium.

  • Designed to be easy on digestion, reducing the chance of stomach upset.

  • Often recommended as a good all-around magnesium supplement.


Key Differences Between Bisglycinate and Glycinate

Here’s a side-by-side comparison to make things simple:

Feature Magnesium Glycinate Magnesium Bisglycinate
Absorption High High (slightly enhanced)
Tolerance May cause mild digestive upset Gentler on the stomach
Best For Stress relief, relaxation, sleep Sensitive digestion, general use
Structure One glycine molecule Two glycine molecules

 

👉 Takeaway: If your goal is better sleep or relaxation, glycinate is often the go-to. If you have a sensitive stomach or want a supplement for general wellness, bisglycinate may be the better fit.


Which Magnesium Is Right for You?

The right choice depends on your body and your goals:

  • Choose Magnesium Glycinate if:

  • Choose Magnesium Bisglycinate if:

    • You have a sensitive stomach or often experience digestive upset.

    • You want a gentle, daily-use magnesium that supports multiple functions.

  • Can You Take Both?
    Yes — some people use different forms at different times. For example, bisglycinate for daily health support and glycinate at night for relaxation. Always consult your healthcare provider for dosage guidance.


Benefits of Magnesium in General

Regardless of which form you choose, magnesium plays an essential role in:

  • Supporting muscle relaxation and recovery

  • Promoting calm and better sleep quality

  • Helping regulate nerve and heart function

  • Assisting with energy production

  • Supporting bone and metabolic health


What About Other Forms of Magnesium?

While glycinate and bisglycinate are two of the most popular, you’ll also see:

  • Magnesium Citrate → often used for digestion and occasional constipation relief.

  • Magnesium Oxide → inexpensive but less absorbable; used for specific conditions.

  • Magnesium Threonate → studied for potential cognitive benefits.

These forms may be helpful, but for most people, glycinate or bisglycinate offer the best balance of absorption and tolerance.


Final Thoughts

Magnesium bisglycinate and glycinate are both excellent choices if you’re looking for a supplement that’s easy to absorb and supports overall health. While they’re nearly identical, the subtle difference in formulation can impact how your body tolerates them.

  • If you’re seeking better sleep and stress relief, magnesium glycinate may be best.

  • If you have a sensitive stomach or want a daily-use option, magnesium bisglycinate is likely the better choice.

Ready to try it for yourself?
Explore our Magnesium Supplements Collection to find trusted Canadian brands, NPN-approved products, and fast shipping across Canada.

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Frequently asked question

What is magnesium bisglycinate vs glycinate?

Magnesium glycinate has one glycine molecule, while bisglycinate has two. Bisglycinate is typically easier on digestion, while glycinate is widely used for relaxation and sleep.

Which magnesium is best for sleep?

Magnesium glycinate is commonly chosen for sleep support due to its calming effect on the nervous system.

Which magnesium is gentler on the stomach?

Magnesium bisglycinate is generally gentler on digestion and is often recommended for people with sensitive stomachs.

Can you take both forms together?

Yes, it’s generally safe to take both forms, but consult your healthcare provider to determine the right dosage for your needs.

Is magnesium bisglycinate the same as magnesium glycinate?

They are very similar forms, but bisglycinate has two glycine molecules, making it gentler on digestion compared to standard glycinate.

Which form of magnesium is best absorbed?

Both bisglycinate and glycinate are highly absorbable, but bisglycinate may be slightly more bioavailable and better tolerated by sensitive stomachs.

Can I take magnesium bisglycinate or glycinate every day?

Yes, both forms are safe for daily use within recommended dosages. Always follow label directions or consult a healthcare provider.

Which magnesium form is better for stress and relaxation?

Magnesium glycinate is often preferred for stress and relaxation because of its calming effect on the nervous system.

Which magnesium is best for sleep?

Magnesium glycinate is commonly chosen for sleep support because of its calming effect on the nervous system.

Which magnesium is easier on the stomach?

Magnesium bisglycinate is usually considered gentler and less likely to cause digestive upset.

Can I take magnesium every day?

Yes, both glycinate and bisglycinate are safe for daily use within recommended dosages. Always follow the product label or your healthcare provider’s advice.

Which form is best absorbed?

Both are highly absorbable, but bisglycinate may have a slight edge in tolerability and absorption efficiency.

Can I combine different forms of magnesium?

Many people do. For example, bisglycinate for daily health and glycinate for nighttime relaxation. Speak with your healthcare provider to find the right balance for you.